The hotel night clerk, Bart Bromley is a highly intelligent young man on the Autism spectrum. When a woman is murdered during his shift, Bart becomes the prime suspect. As the police investigation closes in, Bart makes a personal connection with a beautiful guest named Andrea, but soon realizes he must stop the real murderer before she becomes the next victim.

A young woman who escapes from her group home hoping to get her Star Trek script produced in Hollywood. With her sister and psychiatrist at her heels, she must conquer a new world full of challenges.

The show is about a young surgeon with autism who is recruited to work at a pediatric unit of a hospital. The hospital is prestigious with many of the toughest cases a surgeon could ever see, but with autism comes clarity that most surgeons will never have. The television series focuses on the relationship between the doctor and patient, and how a man who cannot relate to the people who he tries to help.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.